Inducing autophagy
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چکیده
منابع مشابه
Inducing autophagy
Autophagy is a lysosomal-mediated catabolic process, which through degradation of different cytoplasmic components aids in maintaining cellular homeostasis and survival during exposure to extra- or intracellular stresses. Ammonia is a potential toxic and stress-inducing byproduct of glutamine catabolism, which has recently been found to induce autophagy in an MTOR independent way and support ca...
متن کاملrapamycin enhances hbv production by inducing cellular autophagy
conclusions these results indicated a potential explanation for reactivation of hbv infection when patients with hepatitis receive rapamycin. results in hepg2.2.15 cells, hbv dna and hbsag increased when host cells were treated with rapamycin and the effect was reversed by autophagy inhibitor, 3-methyladenine (3-ma). materials and methods hepg2.2.15 cells were treated with rapamycin to induce a...
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A utophagy, the process of “selfeating” within cells, has been controversial in cancer since it was first linked to the disease in 1999. Because autophagy can either suppress or promote tumors, depending on the context, the field has been marked by both confusion and unwillingness by drug companies to get involved in therapies. But that’s changed. A consensus is emerging that it’s the tumor pro...
متن کاملLuteolin Promotes Cell Apoptosis by Inducing Autophagy in Hepatocellular Carcinoma.
BACKGROUND/AIMS Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is a leading cause of cancer-related death worldwide. Luteolin, a flavonoid from traditional Chinese medicine, shows anti-cancer activity in many cancer cells, including HCC. However, the mechanism underlying the action of luteolin in HCC, especially its role in regulating cell autophagy, remains uncl...
متن کاملRapamycin Enhances HBV Production by Inducing Cellular Autophagy
BACKGROUND Some reports revealed that rapamycin could reactivate HBV infection. However, the mechanism has not been clearly explained. OBJECTIVES In this report, we studied the mechanism by which rapamycin enhances HBV replication and expression by inducing cellular autophagy. MATERIALS AND METHODS HepG2.2.15 cells were treated with rapamycin to induce autophagy. Autophagosomes were observe...
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ژورنال
عنوان ژورنال: Autophagy
سال: 2013
ISSN: 1554-8627,1554-8635
DOI: 10.4161/auto.26863